Conference Details

Abstract :

Overtime due to many external and internal factors the genomes of various organisms go through rearrangement and mutations. The study of genome evolutions is done well by the understanding of this action. The three important ones which affect the genome changes mostly are recombination, transposition, and mutation. Gene sequences are represented using permutation. Two organisms are genetically related if their genomes are closely comparable to one another else they are not. Similarity of two genomes can be measured by finding how simple it is to change one genome into another using certain operations such as reversals. Thus, we get the reversal distance, the distance to change one genome to another by implementing sorting by reversal. To find the reversal distance, firstly we need to find the synteny blocks of the genome variants. Synteny blocks are converted into permutations and then with implementation of sorting by reversal algorithm we find the number of reversals needed to transmute permutation of rearranged genome to identity permutation. Various tools are used to find synteny blocks from the genome datasets and convert them into permutations. So, by studying the genome rearrangement we get an insight on how the genomes are rearranged and how it will affect the genomic architecture of the organism in future.